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“But I will say this: When the scientists of the future show up at my house with robot eyes and they tell me to try them on, I will tell the scientists to screw off, because I do not want to see a world without him." Isaac is one of the supporting characters of The Fault in Our Stars.
He had an eye cancer known as retinoblastoma, he also had one glass eye and one real eye, then the other real eye was removed and he is NEC.
He and Augustus are best friends, and through him Augustus befriends Hazel.
He was previously in a relationship with Monica, until she broke up with him upon hearing he would go blind.
Isaac is known to like video games and has a wide sense of humor, as evidenced when Hazel visits him after he undergoes his surgery; even through the most intense pain he jokes, "Come over here so I can examine your face with my hands and see deeper into your soul than a sighted person ever could".
In The Fault in Our Stars, Isaac is described as being a long-faced, cool, skinny guy with long blond hair swept over one eye, and having rather large, thick glasses.
In the movie, the two features listed that he doesn't have is his long blonde hair and hair that swept over his glass eye.
Augustus had attended the Support Group at Isaac's request to support him under the stress of going blind.
It was thanks to Isaac that he and Hazel met in the first place.
They hang out a lot and not much other than what is portrayed is said about their friendship - but it is evident that they're very close.
Augustus seems to be Isaac's best friend even after both eyes are removed.
Isaac enjoys Hazel's company and they befriended each other very early in the book.